Procognia (Israel) Ltd. and Seahorse Bioscience successfully completed the first stage in a combine study demonstrating the synergistic effect of their technologies to expand and significantly improve biopharmaceutical drugs development while reducing dramatically development cost, risks and time to market - 25/04/2010

The experiment combined the unique technological high throughput capabilities of Procognia for accurate and fast glycoanalysis and that of Seahorse Biosciences to simultaneously run a wide variety of production conditions on approximately 300 miniature bioreactors, which accurately simulate the performance of an industrial bioreactor.

Since most of the process parameters (e.g. cell line, media, temperature, pH, etc.) which affect the productivity of biopharmaceutical processes have a major impact on the glycosylation profile, the goal of the study was to implement quality by design methodology to define the effect of process parameters on the glycosylation profile of glycoprotein drugs.

In this study about 100 different process combinations have been analyzed in parallel within a couple of weeks and the optimal conditions' combination which result in the highest yield and targeted glycosylation profile have been identified.

The combination of Procognia and Seahorse technologies provide biopharmaceutical companies a unique capability to significantly streamline the development of biopharmaceuticals production process and to achieve the highest product quality, safety and productivity while reducing development time from many months to weeks, reducing expenses and development risks.

These results will be presented at the Cell Culture Engineering XII conference, April 25 - 30, 2010, Banff, Alberta, Canada


About Seahorse Bioscience:
The Seahorse SimCell system is an automated cell culture manager that agitates, feeds and pH balances Bioreactor Cards - microplate-sized disposables containing six microculture chambers that mimic bench-scale bioreactors. The SimCell optimizes biologic drug manufacturing by to selecting clones, optimizing medium, and determining optimum process conditions. Founded in 2001, Seahorse is headquartered in Billerica, MA with a European sales office in Copenhagen Denmark.